Studies suggest that for an average long term Kratom user, it will take around 5.33 days to completely remove the drug from their system. However, there can be significant variation from user to user based upon a number of factors such as alkaloid content of the drug and weight, age, gender and efficiency of metabolic system of the user.
There are a number of different alkaloids present in Kratom leaves. The type and amount of these alkaloids can significantly vary depending upon the plant the leaves have been extracted form. However, mitragynine is the predominant type of alkaloid present in all types of Kratom plants. Some plants may contain higher amounts of mitragynine compared to others.
Kratom plants grown in Southeast Asia tend to have the highest content of mitragynine. On the other hands, the ones grown in green houses outside Southeast Asia tend to have negligible amounts of it. Consuming Kratom leaves with higher mitragynine content will elicit a stronger response and also, mitragynine will tend to stay in the system for longer durations of time. Leaves with low amounts of mitragynine tend to contain other alkaloids in higher amounts but they are unlikely to be detected on a drug test.
It is also important to consider the source Kratom has been obtained from. Some dealers tend to contaminate the drug with other substances such as spice etc. These additional chemicals administrated in the body can also be detected by a drug test.
The time taken for the removal of same amount of the drug, taken at the same time by two different individuals may vary depending upon the factors given below:
Age: Usually, older people (65+) are not able to metabolize Kratom as fast as younger people do. It may be due to a number of reasons such as younger people tend to have a faster metabolic rate and better physical health.
Body mass index: The height and weight of a person also influence the time taken for Kratom removal. A person with more body mass will remove Kratom at a faster rate compared to a person with low body mass.
Body fat content: People with higher fat content tend to retain the drug for longer periods of time. It can be attributed to the hydrophobic and lipophilic nature of mitragynine. It becomes lodged in the fat content of the body and is removed slowly over time.
Genetics: Although the kinetics of Kratom are not fully understood yet, certain enzymes involved in the process of Kratom metabolism are produced as a result of expression of certain genes present in the genetic makeup of a specific individual. Metabolic rate of a person is also determined by their genes.
Liver function: Liver function as well as the overall health of a person influences clearance rate of Kratom. It is suspected that people with liver impairment take longer to remove the drug from their system.
Renal function: A significant amount of Kratom alkaloids is excreted via urine. It shows that kidneys are involved in the excretion of large amounts of drug. Severe forms of renal impairment are known to affect the clearance rate of Kratom. The half life of the drug is also extended in such individuals.
Polydrug use: Before any other drugs are used in combination with Kratom, it is important to know how they interact with Kratom. Some drugs can slow down the clearance process of Kratom while the others can speed it up.
The time taken for the clearance of Kratom is dependent on its frequency of use as well. For frequent users, it takes longer to clear it out of their system since it becomes incorporated in certain body tissues such as fat cells and hair. Also, frequent users are more likely to take higher doses to cope with tolerance. It further promotes its accumulation in body tissues.
With frequent use, the system of the user becomes adapted to function in the presence of drug so it doesn’t metabolize it as efficiently as it normally would.
The time drug stays in the system for depends upon the amount of it consumed. It is important to consider the potency of the drug since the alkaloid content may vary as mentioned earlier. Taking larger amounts of the drug rich in mitragynine will extend the time taken for its removal.