A lot of factors can influence the clearance rate of Vicodin. They are divided into four main categories, individual factors, doses, frequency, and use of other drugs.
- Age:As a person reaches an age of 60+, the ability of the body to actively metabolize the drug is significantly decreased. Young individuals can metabolize the drug at a much faster rate.
- Body size: A large individual consuming the same amount of the drug will metabolize it at a faster rate compared to an individual of small body size. So a large body size will lead to an early excretion and clearance of drug from the body.
- Genetics: Some individuals have a more efficient hepatic enzymatic system than others. This is genetically determined by the presence of alleles for such characteristic enzymes. Some people exhibit a poor metabolism because of their less-efficient enzymes compared to average population.
- Food Intake:Food intake before drug ingestion also influences the pharmacokinetics of Vicodin. A full stomach leads to the slow absorption of the drug as more of the blood is diverted towards the absorption of digested food particles.
- Liver and kidney Functions:Liver and kidney are the two main organs involved in the direct processing of drug. Any impairment or dysfunction of liver or kidney can lead to the disturbance in metabolism and excretion of the drug. As a result, more time will be taken by the drug to get cleared from the system.
- Urinary pH:A low pH promotes the excretion of Vicodin. Alkalinity or high pH is associated with more drug reabsorption from the kidney tubules and hence, higher levels of Vicodin in the body.
Frequency of Vicodin use:
The frequent use of the drug requires a lot more time to get cleared from the system. This is due to the fact even before the previous dose clears out from the system, more drug is administrated in the body. As a result, it starts accumulating in body tissues. Norhydrocodone, a metabolite of Hydrocodone has a strong propensity for accumulation and thus, prolonging the clearance time.
Using other medicines:
Some drugs interact with the enzymes responsible for Vicodin metabolism. Methadone, Codeine, Delavirdine, Yohimbine, Sertindole, and Perphenazine slow down the activity of concerned enzymes. Rifampicin and Dexamethasone tend to speed-up the metabolism of Vicodin.