Percocet is the brand name given to a medicine composed of two main drugs, Oxycodone and Acetaminophen. The drug was first introduced as an intravenous formulation in Germany. It was widely used for the treatment of the pain of World War I victims. In 1976, the drug got officially approved and oral tablets were manufactured for the management of moderate to severe pain. Percocet acts on the opioid receptors in the central nervous system. This leads to a reduced level of cAMP and increased level of neurotransmitters like dopamine, acetylcholine, norepinephrine, and GABA. Effects such as elevated mood, euphoric feelings, and mental relaxation, get initiated. The long-term use causes the development of tolerance, dependence, and addiction. Furthermore, the abuse leads to the depletion of body’s endorphins. The adverse effects sustain as long the person continues to abuse the drug and Percocet particles stay within the body system.