There are a few factors that may affect how long oxycodone stays within your system. These include the following:
Age. The ability of a person to clear the drug from his or system is sometimes determined by age. For instance, younger individuals have a much faster clearance rate than the elderly because of the kidney’s efficiency in eliminating the drug.
Body Mass. In general, the higher the Percocet dose that an individual takes in respect to his/her weight and height, the longer the drug will be retained. This means that a lightweight person who takes ten milligrams of Percocet will likely take a little bit longer to eliminate the drug from the system than a heavyweight individual.
Hydration and Food Intake. Whether you take the drug on an empty stomach or with food, it could influence excretion, metabolism and absorption. While the extent to which Percocet’ pharmacodynamics is influenced by the amount of water consumed and food ingestion remain unclear, a person who tales the drug will full stomach may jeopardize its absorption. Also, certain drinks and foods can reduce metabolism, which could possibly prolong clearance from the drugs.
The Ability of the Kidney and Liver to Function. Percocet is extensively metabolized by enzymes in the liver. When a person has taken Percocet with hepatic impairment, the drug’s metabolism may be prolonged, which may lead in an extended clearance time.
Therefore, the hepatic function affects the speed rate of the excretion of Percocet from the system. The drug contains acetaminophen that is metabolized in the liver. This means that the clearance time will be increased by up to two days by those with renal impairment because the liver wouldn’t metabolize the drug effectively. Thus, the substance will linger in the system for a longer period of time.
Urine Alkalinity or Acidity. The urine’s alkalinity or acidity also affects the rate at which the drug is excreted from the system. If you have an acidic urine, it will be faster to eliminate Percocet from your system. Therefore, it is important to take a diet that is rich in acidic foods if you have ingested the drug. On the other hand, a diet that is rich in foods that contain alkaline can slow down the kidney’s ability to excrete the substance from the system.
Disease. There are certain diseases that affect the brain, kidneys, liver and heart, affecting how the body metabolizes the drug.