Fentanyl is a strong synthetic analgesic which belongs to the class of opioids. The drug has a chemical similarity with morphine but it is many times stronger than it. The potency of Fentanyl is fifty to hundred times more than the morphine. It is a schedule II drug which is prescribed to treat the patients with a severe pain. The pain of surgery is managed with Fentanyl. The chronic pain of various cancerous diseases is also treated with it. Trade names of the drug include ‘Actiq’, ‘Sublimaze’ and ‘Duragesic’. Fentanyl has a high potential for abuse and the addiction. The drug is used for the medicinal purposes but the euphoric effects of the drug have led to its wide misuse by the people. It is a very notorious street drug. The 2015 statistics of USA showed that about 9,580 people died from drug overdose, Fentanyl was one of those drugs contributing a greater percentage of death from overdose.