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Dilaudid Abuse and Addiction

How Long Does Dilaudid Stay in Your System?

Hydromorphone also called as dihydromorphinone comes under a brand name ‘Dilaudid’. It belongs to the opioid class of drugs and has an almost similar mechanism of action as morphine. To state more accurately, Hydromorphone is a ‘hydrogenated ketone’ derivative of Morphine. Dilaudid is an analgesic that is used to control the pain of moderate to severe intensity. It is mostly used in the hospitals in intravenous form as the bioavailability of drug gets significantly reduced in oral forms. The drug carries a high potential for abuse and addiction. Moreover, the potency is stronger than morphine. It also produces more severe adverse effects like dizziness, hallucinations, hormonal imbalances, and neurotoxicity. It is important to clear the traces of drug particles in order to ward-off these negative effects. The detoxification process is based on the half-life, which further depends on the route used for drug administration.

How long does Dilaudid stay in your system?

Dilaudid is available in different formats, oral tablets, liquid, suppositories, and injectibles. The usual therapeutic dose of Dilaudid ranges from 1-10mg. Other than medical uses, it is a popular recreational drug to get the euphoric and pleasant effects. People abusing the drug also use other modes such as crushing, snorting, and chewing for getting a rapid onset of effects. It is also combined with other potent drugs to achieve a better High.

Dilaudid is administered through different routes into the body. The half-life is different for each mode of administration. When an oral tablet or syrup form is taken, peak concentration levels in the blood are reached within 30-60 minutes. The half-life with oral administration is approximately 4.1 hours. After the Intravenous dose, the half-life of Dilaudid becomes 2.3 hours. The complete elimination of drug will take almost 24 hours after the last dose. There are many factors that can affect the rates of clearance of Dilaudid from the body.

Factors that influence how long Dilaudid stays in your system

There are many variables that influence the rate of drug elimination from the body. They act as the reasons behind different clearance timelines in two individuals, who have consumed exactly the same amount of Dilaudid.

Individual Attributes: These include age, height, weight, genetics, liver, and kidney functions.

  • Age:As the person becomes older, the system becomes less efficient as cells replacement and growth are affected by the aging process. A young individual has faster metabolism and excretion rates.
  • Body Size:People having a larger body size tend to metabolize the drug more rapidly in comparison to people having a smaller body size.
  • Genetics: The genetics play a major role as all the enzymes are genetically determined. Some of the people have a predisposition in the form of such alleles that can metabolize the drug more rapidly than others. This genetic variation alters the functioning of CYP2D6 enzymes that affect the metabolic rates.
  • Liver and kidney Functions: The proper functioning of these two organs can cause a rapid metabolism and excretion. When the organs get affected by a disease process, the functioning gets disrupted and more of the drug continues to circulate in the body. Those who have suffered a renal failure can have a Dilaudid Overdose even in small quantities.
  • Frequency of Dilaudid ingestion: The more frequency of drug intake requires a more quick metabolism and excretion. The body has a limited capacity to work. Moreover, as the body becomes dependent on the drug, it develops mechanisms to retain the drug in order to avoid the withdrawal effects.
  • Drug Interactions: There are drugs that induce the CYP2D6 enzymes; these include dexamethasone, rifampicin, and haloperidol. The inhibitors include SSRI’s, Amiodarone, Clomipramine, Haldol, Diltiazem, and Perphenazine.
  • Duration and doses of Dilaudid: People abusing Dilaudid for prolonged duration take more time for detoxification and also suffer more adverse withdrawal symptoms. The higher doses are also associated with a slow clearance rate.

Dilaudid absorption, metabolism, and excretion:

Hydromorphone has high lipid solubility. It can easily cross the blood brain barrier and also spreads to other tissues of the body due to an ease of passage across the cell membranes. On a 1 mg basis, Hydromorphone is said to be 5 times more potent than morphine. It is due to its greater penetrance and distribution in the central nervous system. The drug is absorbed through the gastrointestinal lining into the portal circulation in cases of oral ingestion of drug. In the case of IV injections, the drug is directly entered into the blood circulation and effects get initiated within few minutes. The onset of action in oral form is 15 to 30 minutes. It is 15 minutes in case of intramuscular injections, 5 minutes in IV injections, and up to 30 minutes through rectal administration.

Hydromorphone undergoes extensive metabolism in the liver by CYP2D6 enzymes. It is converted to hydromorphone-3-glucoronide and reduction metabolites. Almost 95 % of Dilaudid is converted into hydromorphone-3-glucoronide, rest of the drug changes into 6-hydroxy metabolites.

Only a little amount of Dilaudid is eliminated in an unchanged form in the urine. Majority of the drug is eliminated as hydromorphone-3-glucuronide and minor quantities as hydroxyl metabolites. The systemic clearance is about 1.96liters/minutes.

Different types of Dilaudid drug tests:

There are many tests that are used for the detection of Dilaudid. The urine tests, blood tests, hair analysis, and oral fluid tests are some of the common tests used for Dilaudid.

  • Urine Tests: A sample of fresh urine is collected from an individual. The time duration for which the drug remains detectable is quite variable among users. Urine tests are non-invasive and easy to perform as compared to other modalities of testing. Therefore, it is the commonly employed test for numerous purposes. The amount of Dilaudid stays detectable up to 2 to 3 days after the last dose. However, the trace quantities can be recognized for up to a week.
  • Blood Samples: It is not a routinely performed test as it is invasive and inconvenient. The tests are mostly used in the hospital settings where repeated tests may be required for a proper monitoring in cases of overdose, intoxications or other harmful signs. The advantage associated with blood samples is that accurate quantification can be done. The test offers a narrow detection period, up to 24 hours. Therefore, it is reserved for the acute cases.
  • Hair Tests: The hair analysis is also not a routinely performed test. However, it has many implications in several criminal and postmortem cases. The drug gets accumulated in the hair follicles. Even with few doses of consumed drug, some amount tends to get settled in the hair follicles. It is an easy and convenient test. Moreover, Dilaudid can remain detectable about 3 to 6 months after the last dose. This gives a lot of benefit in the research studies as well.
  • Saliva Tests: These tests are more useful in cases of oral administration of drug. The usefulness of test diminishes with other routes of administration. However, the biggest advantage is an ease of detection and rapid quantification as drug appears readily in the oral fluids. They can also be used in acute cases of overdose. The window of detection is also longer, about 2 to 3 days after the final dose of Dilaudid.
Tips to clear Dilaudid from the system faster:

Some ways can help a faster elimination of drug from the body. However, an exact time cannot be estimated with these methods. It must also be kept in mind that these tips are not medically proven. It is essential to check with your doctor before adopting these procedures.

  • Discontinue the drug: It is not a special tip but some people think that using the smaller quantities won’t affect the elimination time of drug. In reality, each of the bits of the drug takes time to undergo metabolism and excretion.
  • There are many substances that act as the enzymatic inducers. Many supplements are also available that can enhance the functioning of drug. They all should be taken after proper consultation as they can do more harm to a person if not priorly checked.
  • The acidic pH increases the rate of drug clearance. There are many foods like meat, tea, chocolates, brown rice and fruit juices. The acidic ph tends to push more of the drug through the tubules into the final pathway of urine formation. It acts to speed-up the process rather than slowing it down as in cases of alkaline pH.
  • Stay hydrated by drinking the ample amount of water. This regulates the urinary flow rate and more of the drug enters the kidneys and thus gets excreted out from the body.
  • Indulge in regular exercise as it improves the blood circulation through all the organs and systems of the body. The improved blood flow to liver and kidneys increase the rate of Dilaudid metabolism and excretion respectively.