There are different ways for the detection of Codeine in the body. The variety of test includes urine tests, blood tests, hair analysis, and salivary tests.
The fresh urine samples are collected from the patient and tested in laboratory for the detection of codeine metabolites. Urine tests are non-invasive and provide a longer duration of stay of drug particles in the samples. The body should have 2000 ng/ml of Codeine in order to avoid the false positive results. Codeine and its metabolites appear in urine within few hours of ingestion and stay up to 24 hours. After 1 day, it is highly unlikely to detect Codeine in urine. Some tests like EMIT (enzyme multiplied immunoassay technique) and GC/MS (gas chromatography/mass spectrometry) can detect Codeine even up to 52 hours after the last ingestion of drug. The cases of renal impairment may lead to slow excretion, which takes more time, and thus it becomes important to know as to how long does Codeine stays in your urine.
It is a less commonly used modality for identification of drug. Hair follicles from the head are plucked and sent for laboratory analysis. The research studies have confirmed the presence of Codeine within 15 minutes of 120 mg administered dose. A one cm new hair growth can show the traces of Codeine. The detection period stays for as many as ten weeks or 70 days, making it a useful test for various purposes. The hair color affects the detection with a lesser probability in cases of red or blonde hair. Moreover, the metabolites like glucuronides and morphine are not detectable in hair.
These tests are quick to perform and are non-invasive. Saliva tests are a preferred modality in many circumstances. Codeine concentrations peak at 30 minutes to 2 hours after administration of drug. The test can detect the drug within 15 minutes and up to 24 hours after consumption. A drawback associated with it is that other substances in the saliva can interfere with the test results.
They are the less performed tests due to a short window period of detection and invasive nature. However, they become useful in cases of overdose and cases of Codeine-related complications. After collection of the blood sample, it is quickly analyzed to generate the results. Codeine can be detected within minutes of ingestion, and thus you need to know how long does Codeine stays in your blood after last intake. Peak levels are attained in 1 to 2 hours. The blood tests can detect the drug within 16 hours of the final dose.