The prolonged use of amphetamines alters the structure of the brain in such a way that it is no more able to function without the drug and the condition is termed as ‘addiction or dependence’. The use of amphetamines has also been associated with the production or aggravation of pre-existing mental disorders such as depression and anxiety. The drug is abused by the people who take it for recreational purposes as well as those who take it for therapeutic purposes. Even therapeutic use of amphetamine has been known to develop dependence. Looking for signs and symptoms of amphetamine abuse and addiction can be helpful to figure out when its use has become a problem.