Fentanyl is a very potent and highly addictive drug. The risks of overdose are also very high with the use of Fentanyl. The drug in high dose causes a severe respiratory depression and can lead to an immediate death. From the start of 2000, the numbers of Fentanyl addicts are increasing in the US. Fentanyl addiction requires proper rehabilitation centers for the treatment. A through medical supervision is needed to closely monitor the patient and make his path towards the recovery process. There are different treatment options that are given in combination for curing the addiction. The psychotherapies are also included with the detoxification process as per the relevant treatment protocols. It significantly reduces the relapse rates.